UPDATE 2.15pm: Fire crews have put out the blaze which destroyed a caravan on the Burnett Hwy near Thangool.
A Queensland Fire and Rescue spokeswoman said the incident happened near the Thangool dump.
One lane of the highway has reopened.
There is believed to be no injuries.
BREAKING, 12.10am: A caravan has been destroyed by fire and the Burnett Highway is blocked near Thangool.
Details are sketchy but it's believed the incident involving a car towing a van happened near the transfer station.