NICK Kyrgios will forge into uncharted territory at this week's depleted US Open, clashing for the first time in a grand slam main draw with a fellow Australian.
The 14th seed opens his campaign against Queenslander John Millman in a tournament diluted by the absence of defending champion Stan Wawrinka, Novak Djokovic, Milos Raonic and Kei Nishikori.
The only time Kyrgios, 22, has battled an Australian at grand slam level was in first-round qualifying against Greg Jones in New York in 2013.
Kyrgios downed Jones in straight sets and went on to reach the main draw, losing in the first round to David Ferrer.
Millman, 28, and Kyrgios have never played.
Ranked No.176 in the world, Millman has not played a compatriot at the highest level since losing in straight sets to Bernard Tomic in the third round of the 2016 Australian Open.
Kyrgios will lead an seven-man contingent at Flushing Meadows after John Patrick Smith qualified.
Confident after reaching the Cincinnati Masters final last week, Kyrgios has been receiving treatment on his right hip while practising with American Jack Sock in Kansas.
The Open also marks the return of embattled former world No 17 Tomic, who has not played since a traumatic exit from Wimbledon.
If the Gold Coaster fails to string together wins in New York - and he plays Luxembourg veteran Gilles Muller first-up - he will plummet out of the top 100.
Sydney's Jordan Thompson, who is building a giant-killing reputation after toppling world No.1 Andy Murray at Queen's Club, meets 13th seed Sock in the opening round.
South Australian Thanasi Kokkinakis starts against Serbian Janko Tipsarevic, while Smith faces Italian Thomas Fabbiano.
Wildcard Alex De Minaur has an intimidating draw - a first-round appointment with Austrian enforcer Dominic Thiem.
Daria Gavrilova heads a four-woman band, intent on winning her first match at the highest level since January's Australian Open after successive first-round exits in Paris and London.
Gavrilova plays US qualifier Allie Kiick, while fast-rising Ash Barty takes on Croat 21st seed Ana Konjuh.
Ajla Tomljanovic and Arina Rodionova play Swede Johanna Larsson and Holland's Richel Hogenkamp, respectively.
Roger Federer chases his 19th major overall, sixth Flushing Meadow title and first US Open crown since 2008.
Bidding to snaffle three majors in a season for the first time in 2007, the 36-year-old is ruling TAB $2.50 favourite after compiling a stunning 35-3 2017 record.